Enhancing Detection of Subclinical End-Organ Damage

Enhancing detection of subclinical end-organ damage: echocardiographic left ventricular strain holds up a mirror to the brain.

Enhancing Detection of Subclinical End-Organ Damage: Echocardiographic Left Ventricular Strain Holds Up a Mirror to the Brain Running title: Kizer; LV strain and subclinical cerebrovascular disease

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Aldosterone and end-organ damage.

PURPOSE OF REVIEW This review highlights recent clinical studies demonstrating the contribution of aldosterone to cardiovascular mortality, vascular dysfunction, and renal injury in the context of advances in our understanding of the molecular biology of aldosterone. RECENT FINDINGS Mineralocorticoid receptor antagonism reduces mortality in patients with congestive heart failure and following...

Inflammation, immunity, and hypertensive end-organ damage.

For >50 years, it has been recognized that immunity contributes to hypertension. Recent data have defined an important role of T cells and various T cell-derived cytokines in several models of experimental hypertension. These studies have shown that stimuli like angiotensin II, deoxycorticosterone acetate-salt, and excessive catecholamines lead to formation of effector like T cells that infiltr...

Tissue Engineering: A Biological Solution for Tissue Damage, Loss or End Stage Organ Failure

In recent years the science of tissue engineering has emerged as a powerful tool for the development of a novel set of tissue replacement parts and technologies. Recent advances in the fields of biomaterials, stem cell technologies, growth factor field and biomimetics have created a unique set of opportunities for investigators to fabricate lab-grown tissues from combination of extracellular ma...